Health Graying Hair Linked To Immune Response, Study Finds

11:31  07 may  2018
11:31  07 may  2018 Source:   medicaldaily.com

This Is What Fast Food Actually Does to Your Immune System

  This Is What Fast Food Actually Does to Your Immune System ***ImagePlaceholder*** http://www.besthealthmag.ca/wp-content/uploads/2018/02/Fast-food-burger-chicken-nuggets-pop.jpg photo credit: shutterstock Don’t get enough sleep? Booze too much? Stressing out? These everyday habits could be ruining your immune system, but the worst culprit may be your fast food habit. A recent study out of the University of Bonn suggests that a typical 'Western diet' (a lot of red meat, sugar, and saturated fat and not much fiber -- basically synonymous with fast food) can kick the immune system into overdrive, causing inflammation. The study, published in the journal, Cell, goes on to connect that inflammatory response to serious conditions like cardiovascular diseases (read: stroke or heart attack) and type 2 diabetes, which itself can lead to cardiovascular diseases, as reported by Science Daily. Researchers, led by Eicke Latz, MD, PhD, director of the Institute for Innate Immunity of the University of Bonn in Germany, placed mice on a Western diet and observed that after only one month, the mice had an inflammatory response akin to that triggered by a serious bacterial infection. 'Fast food thus causes the body to quickly recruit a huge and powerful army,' noted the University of Bonn's press release, as that process notably increases the immune cells in the mice's blood. Even worse? The immune response isn't reversible, the scientists discovered.

A new study on mice offers insights into why some people’s hair may turn gray in response to a serious illness or chronic stress. In this case, an unexpected link was found between gray hair , the transcription factor MITF, and innate immunity .

In this case, an unexpected link was found between gray hair , the transcription factor MITF, and innate immunity . If MITF's control of the interferon response is lost in melanocyte stem cells, hair - graying results. Furthermore, if innate immune signaling is artificially activated in mice that are

Gray Hair© Gray Hair Gray Hair

What is the science behind our hair turning gray? Researchers from the University of Alabama at Birmingham have a possible answer and it may also explain why vitiligo patients develop unpigmented patches of skin.

The study titled "A direct link between MITF, innate immunity, and hair graying" was published in the journal PLOS Biology on May 3.

"My lab harnesses the power of mouse models of hair graying to better understand stem cells and aging. The stem cells we study are the melanocyte stem cells in the hair follicle, which are the stem cells that are essential for producing melanocytes," explained lead study author Melissa Harris, an assistant professor of biology at the University of Alabama.

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A new study on mice offers insights into why some people’s hair may turn gray in response to a serious illness or chronic stress. In this case, an unexpected link was found between gray hair , the transcription factor MITF, and innate immunity .

Overactive immune response linked to hair graying . Study Explains One Reason Hair Can Turn Gray . Hair 's graying is linked to innate immune response , activation of which can decrease pigmentation in hair .

Melanocytes are pigment-producing cells responsible for giving your hair its natural color, be it blonde, brown, red or black. But when melanocytes suffer damage as a response to natural aging or a serious illness, the newly grown hair ceases to carry its natural pigment. This is how people develop gray or white hair.

Previously, the research team had found that a protein called MITF (melanogenesis-associated transcription factor) controlled the genes to create hair color pigment. The team examined mice that were bred to develop premature gray hair and found an excessive production of MITF. However, even when they bred mice to produce the protein at lower levels, their fur continued to turn prematurely gray at a similar pace as before.

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In this study , an unexpected link was found among gray hair , the They found that if MITF’s control of the interferon response was lost in melanocyte stem cells, hair - graying resulted. Furthermore, if innate immune signaling is artificially activated in mice that are predisposed to getting gray hair

In the current study , they found that MITF also limits the activity of certain genes that control the immune response to viruses. Top Medical News. Overactive immune response linked to hair graying .

The new research found that MITF may actually turn off genes for an anti-virus, immune protein called interferon. When the researchers triggered an anti-virus response in the mice, it was found that the mice having low levels of this protein ended up losing melanocytes and developing gray fur.

Since this was a mouse study, it remained unclear how far this mechanism could work in the case of human beings. But Harris pointed that it may be one of the possible reasons why some people suddenly develop gray hair in their youth. "Perhaps, in an individual who is healthy yet predisposed for gray hair, getting an everyday viral infection is just enough to cause the decline of their melanocytes and melanocyte stem cells leading to premature gray hair," she said.

Another significant takeaway from this discovered mechanism is that it may also explain disruptions in skin pigmentation in addition to affecting hair pigmentation.

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  Changes In These 6 Body Parts May Indicate Health Problems Even though they seem unrelated, the condition of your hair may indicate how well your thyroid gland is working. Here are some other ways your body points out health issues. Our external body parts may be sending us important signals about our health. Often, mere changes in color, shape or texture in certain body parts could be signs of an underlying medical issue that should be addressed.

A new study on mice offers insights into why some people’s hair may turn gray in response to a serious illness or chronic stress. Researchers have discovered a connection between the genes that contribute to hair color and the genes that notify our bodies of a pathogenic infection.

In the current study , they found that MITF also limits the activity of certain genes that control the immune response to viruses. Top Medical News. Overactive immune response linked to hair graying .

"These results may enhance our understanding of hair graying. More importantly, discovering this connection will help us understand pigmentation diseases with innate immune system involvement like vitiligo," added co-author William Pavan, chief of the Genetic Disease Research Branch at the National Institutes of Health (NIH).

Vitiligo is a condition that leads to the loss of natural skin color, typically in patches, as cells lose the ability to produce melanin. It affects somewhere between 0.5% to 1% of the human population.

Related video: Scientist Find Cells Linked To Graying Thinning Hair (Provided by Wochit News)

Brown eyes linked to higher chance of SAD .
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